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Article

Injury to repair: Functions of microglia and monocyte-derived cells in ischemic stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Nov 2025

Martynowicz Ryan, Sullivan David P, Batra Ayush

Abstract excerpt

INTRODUCTION: Microglia, the central nervous system's resident immune cells, play a complex role in acute ischemic stroke (AIS), contributing to both neuroprotection and secondary neurologic injury. After ischemic injury, microglia activate and adopt a diverse range of phenotypes, from extremes of pro-inflammatory to anti-inflammatory microglia. Coinciding with microglial activation, AIS triggers infiltration of...

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Topics

Humans
Microglia
Monocytes
Animals
Ischemic Stroke
Brain
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Recovery of Function

Inflammation Mediators

Signal Transduction

Source

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Identifiers

PMID: 40967154
DOI: 10.1016/j.jstrokecerebrovasdis.2025.108422
PMCID: PMC13576645

Provenance

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