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Article

Multi-Zone Visco-Node-Pore Sensing: A Microfluidic Platform for Multi-Frequency Viscoelastic Phenotyping of Single Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Nov 2024

Lai Andre, Hinz Stefan, Dong Alan, Lustig Michael, LaBarge Mark A, Sohn Lydia L

Abstract excerpt

This study introduces multi-zone visco-Node-Pore Sensing (mz-visco-NPS), an electronic-based microfluidic platform for single-cell viscoelastic phenotyping. mz-visco-NPS implements a series of sinusoidal-shaped contraction zones that periodically deform a cell at specific strain frequencies, leading to changes in resistance across the zones that correspond to the cell's frequency-dependent elastic G' and viscous...

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Identifiers

PMID: 39308179
DOI: 10.1002/advs.202406013
PMCID: PMC11578343

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