Quantifying mechanical opacity as a novel indicator for single-cell phenotyping via integrated dynamic mechanical compression and impedance flow cytometry.

Abstract excerpt

A comprehensive understanding of cellular mechanical heterogeneity is essential for identifying phenotypic variations. Impedance flow cytometry offers a high-throughput, label-free approach to assess single-cell electrical properties, yet current methods focus primarily on undeformed cells and overlook mechanical perturbations that may alter cytoskeletal structure and membrane behavior. Here, we present an...

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