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MechanoAge, a machine learning platform to identify individuals susceptible to breast cancer based on mechanical properties of single cells.

EBioMedicine - 1 May 2026

Hinz Stefan, Grøndal Sturla M, Miyano Masaru, Lopez Jennifer C, Cotner Kristen L, Thomsen Taylor, Chen Chang, Hester Edward J, Yee Lisa D, Seewaldt Victoria E, Lorens James B, Sohn Lydia L, LaBarge Mark A

Abstract excerpt

BACKGROUND: Emerging evidence links cellular ageing and biophysical alterations with cancer susceptibility. Existing breast cancer risk models inadequately identify individuals at latent risk, particularly among women without known genetic mutations or family history. Risk is often underestimated or overestimated due to reliance on population-level data and absence of individualised tissue-based markers of breast...

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Identifiers

PMID: 42031621
DOI: 10.1016/j.ebiom.2026.106241
PMCID: PMC13174242

Genes

KRT14
BRCA1
NPS

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