Automated profiling of gene function during embryonic development.

doi:10.1016/j.cell.2024.04.012

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Article

Automated profiling of gene function during embryonic development.

Cell - 6 Jun 2024

Green Rebecca A, Khaliullin Renat N, Zhao Zhiling, Ochoa Stacy D, Hendel Jeffrey M, Chow Tiffany-Lynn, Moon HongKee, Biggs Ronald J, Desai Arshad, Oegema Karen

Abstract excerpt

Systematic functional profiling of the gene set that directs embryonic development is an important challenge. To tackle this challenge, we used 4D imaging of C. elegans embryogenesis to capture the effects of 500 gene knockdowns and developed an automated approach to compare developmental phenotypes. The automated approach quantifies features-including germ layer cell numbers, tissue position, and tissue shape-to...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Embryo, Nonmammalian
Embryonic Development
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Knockdown Techniques
Phenotype

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Identifiers

PMID: 38759650
DOI: 10.1016/j.cell.2024.04.012
PMCID: PMC11166207

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