Article
A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans.
Nature genetics - 1 Feb 2008
Lee Insuk, Lehner Ben, Crombie Catriona, Wong Wendy, Fraser Andrew G, Marcotte Edward M
Abstract excerpt
The fundamental aim of genetics is to understand how an organism's phenotype is determined by its genotype, and implicit in this is predicting how changes in DNA sequence alter phenotypes. A single network covering all the genes of an organism might guide such predictions down to the level of individual cells and tissues. To validate this approach, we computationally generated a network covering most C. elegans...
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