Article
An image analysis toolbox for high-throughput C. elegans assays.
Nature methods - 22 Apr 2012
Wählby Carolina, Kamentsky Lee, Liu Zihan H, Riklin-Raviv Tammy, Conery Annie L, O'Rourke Eyleen J, Sokolnicki Katherine L, Visvikis Orane, Ljosa Vebjorn, Irazoqui Javier E, Golland Polina, Ruvkun Gary, Ausubel Frederick M, Carpenter Anne E
Abstract excerpt
We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans...
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