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Article

De novo inference of systems-level mechanistic models of development from live-imaging-based phenotype analysis.

Cell - 16 Jan 2014

Du Zhuo, Santella Anthony, He Fei, Tiongson Michael, Bao Zhirong

Abstract excerpt

Elucidation of complex phenotypes for mechanistic insights presents a significant challenge in systems biology. We report a strategy to automatically infer mechanistic models of cell fate differentiation based on live-imaging data. We use cell lineage tracing and combinations of tissue-specific marker expression to assay progenitor cell fate and detect fate changes upon genetic perturbation. Based on the cellular...

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Identifiers

PMID: 24439388
DOI: 10.1016/j.cell.2013.11.046
PMCID: PMC3998820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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