Article
Phase and context shape the function of composite oncogenic mutations.
Nature - 1 Jun 2020
Gorelick Alexander N, Sánchez-Rivera Francisco J, Cai Yanyan, Bielski Craig M, Biederstedt Evan, Jonsson Philip, Richards Allison L, Vasan Neil, Penson Alexander V, Friedman Noah D, Ho Yu-Jui, Baslan Timour, Bandlamudi Chaitanya, Scaltriti Maurizio, Schultz Nikolaus, Lowe Scott W, Reznik Ed, Taylor Barry S
Abstract excerpt
Cancers develop as a result of driver mutations1,2 that lead to clonal outgrowth and the evolution of disease3,4. The discovery and functional characterization of individual driver mutations are central aims of cancer research, and have elucidated myriad phenotypes5 and therapeutic vulnerabilities6. However, the serial genetic evolution of mutant cancer genes7,8 and the allelic context in which they arise is...
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