Article
Recipient Versus Donor CYP3A4/5 Genotypes in Adult Liver Transplant Recipients to Achieve Therapeutic Tacrolimus Concentrations Early Post-Transplant.
Clinical and translational science - 1 Sept 2025
Eken Eda, Duarte Sergio, Angeli-Pahim Isabella, Ladd Alexandra D, Warren Curtis, Langaee Taimour Y, Zarrinpar Ali, Johnson Julie A
Abstract excerpt
Tacrolimus is an immunosuppressive agent with difficult dosing due to a narrow therapeutic index and large interpatient pharmacokinetic variability, for which CYP3A5 variation plays a role. Tacrolimus/CYP3A5 pharmacogenetic guidelines exclude liver transplant patients with a donor/recipient CYP3A5 mismatch. We sought to determine the influence of donor vs. recipient CYP3A5 genotype early post-transplant and...
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