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HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer.

Cancer research - 15 Jul 2024

Gnanapragasam Ansley, Kirbizakis Eftyhios, Li Anna, White Kyle H, Mortenson Katelyn L, Cavalcante de Moura Juliana, Jawhar Wajih, Yan Yifei, Falter Reilly, Russett Colleen, Giannias Betty, Camilleri-Broët Sophie, Bertos Nicholas, Cools-Lartigue Jonathan, Garzia Livia, Sangwan Veena, Ferri Lorenzo, Zhang Xiaoyang, Bailey Swneke D

Abstract excerpt

Genome-wide association studies (GWAS) have identified more than a hundred single nucleotide variants (SNV) associated with the risk of gastroesophageal cancer (GEC). The majority of the identified SNVs map to noncoding regions of the genome. Uncovering the causal SNVs and genes they modulate could help improve GEC prevention and treatment. Herein, we used HiChIP against histone 3 lysine 27 acetylation (H3K27ac)...

Topics

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Cell Line, Tumor
Epigenomics
Esophageal Neoplasms
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 38748784
DOI: 10.1158/0008-5472.CAN-23-2397
PMCID: PMC11247317

Genes

UXS1
GABPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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