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Article

Prioritization and functional analysis of GWAS risk loci for Barrett's esophagus and esophageal adenocarcinoma.

Human molecular genetics - 3 Feb 2022

Chen Jianhong, Ali Mourad Wagdy, Yan Li, Dighe Shruti G, Dai James Y, Vaughan Thomas L, Casey Graham, Buas Matthew F

Abstract excerpt

Genome-wide association studies (GWAS) have identified ~20 genetic susceptibility loci for esophageal adenocarcinoma (EAC), and its precursor, Barrett's esophagus (BE). Despite such advances, functional/causal variants and gene targets at these loci remain undefined, hindering clinical translation. A key challenge is that most causal variants map to non-coding regulatory regions such as enhancers, and typically,...

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 34505128
DOI: 10.1093/hmg/ddab259
PMCID: PMC8825357

Genes

COMP
CRTC1
CRLF1
KLHL26
TMEM59L
UBA52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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