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Article

An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling.

The Journal of clinical investigation - 15 Apr 2025

Tao Bolin, Wang Zhenning, Wang Xuanyi, Song Aixia, Liu Jiaxian, Wang Jianan, Zhang Qin, Chen Zhaolin, Wang Zixian, Xu Wenjie, Sun Menghong, Wang Yanong, Zhang Ping, Xu Tao, Wei Gong-Hong, Chen Fei Xavier, Wang Mengyun

Abstract excerpt

Genome-wide human genetic studies have identified inherited cis-regulatory loci variants that predispose to cancers. However, the mechanisms by which these germline variants influence cancer progression, particularly through gene expression and proteostasis control, remain unclear. By analyzing genomic data from a gastric cancer (GC) case-control study (2,117 individuals), focusing on the ubiquitin-specific...

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Identifiers

PMID: 39998882
DOI: 10.1172/JCI179617
PMCID: PMC11996917

Genes

USP47
GC
GLI3

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