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Article

Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers.

International journal of epidemiology - 1 Aug 2015

Sung Hyuna, Yang Howard H, Zhang Han, Yang Qi, Hu Nan, Tang Ze-Zhong, Su Hua, Wang Lemin, Wang Chaoyu, Ding Ti, Fan Jin-Hu, Qiao You-Lin, Wheeler William, Giffen Carol, Burdett Laurie, Wang Zhaoming, Lee Maxwell P, Chanock Stephen J, Dawsey Sanford M, Freedman Neal D, Abnet Christian C, Goldstein Alisa M, Yu Kai, Taylor Philip R, Hyland Paula L

Abstract excerpt

BACKGROUND: Populations in north central China are at high risk for oesophageal squamous cell carcinoma (ESCC) and gastric cancer (GC), and genetic variation in epigenetic machinery genes and pathways may contribute to this risk. METHODS: We used the adaptive multilocus joint test to analyse 192 epigenetic genes involved in chromatin remodelling, DNA methylation and microRNA biosynthesis in 1942 ESCC and 1758 GC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25921222
DOI: 10.1093/ije/dyv050
PMCID: PMC4598798

Genes

GCA
DICER1
EED

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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