A mutation causing increased KATP channel activity leads to reduced anxiety in mice.

Abstract excerpt

Activating mutations in the Kir6.2 (KCNJ11) subunit of the ATP-sensitive potassium channel cause neonatal diabetes. Many patients also suffer from neurological complications. By using mice carrying a human Kir6.2 mutation (Val(59) to Met(59); nV59M mice) targeted to neurones, we show that these mutations also result in altered anxiety behaviour. The light/dark box, successive alleys and elevated plus maze tasks...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anxiety
• Share to Exploratory Behavior
• Share to Maze Learning