Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

doi:10.1038/ncomms6224

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Article

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

Nature communications - 29 Oct 2014

Nones Katia, Waddell Nicola, Wayte Nicci, Patch Ann-Marie, Bailey Peter, Newell Felicity, Holmes Oliver, Fink J Lynn, Quinn Michael C J, Tang Yue Hang, Lampe Guy, Quek Kelly, Loffler Kelly A, Manning Suzanne, Idrisoglu Senel, Miller David, Xu Qinying, Waddell Nick, Wilson Peter J, Bruxner Timothy J C, Christ Angelika N, Harliwong Ivon, Nourse Craig, Nourbakhsh Ehsan, Anderson Matthew, Kazakoff Stephen, Leonard Conrad, Wood Scott, Simpson Peter T, Reid Lynne E, Krause Lutz, Hussey Damian J, Watson David I, Lord Reginald V, Nancarrow Derek, Phillips Wayne A, Gotley David, Smithers B Mark, Whiteman David C, Hayward Nicholas K, Campbell Peter J, Pearson John V, Grimmond Sean M, Barbour Andrew P

Abstract excerpt

Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic dri...

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Identifiers

PMID: 25351503
DOI: 10.1038/ncomms6224
PMCID: PMC4596003

Genes

MDM2
BRCA2
KRAS
MYC
RFC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25351503-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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