Article
Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73.
Proceedings of the National Academy of Sciences of the United States of America - 21 May 2024
Li Dan, Kok Catherine Yen Li, Wang Chao, Ray Debleena, Osterburg Susanne, Dötsch Volker, Ghosh Sujoy, Sabapathy Kanaga
Abstract excerpt
The transcription factor p73, a member of the p53 tumor-suppressor family, regulates cell death and also supports tumorigenesis, although the mechanistic basis for the dichotomous functions is poorly understood. We report here the identification of an alternate transactivation domain (TAD) located at the extreme carboxyl (C) terminus of TAp73β, a commonly expressed p73 isoform. Mutational disruption of this TAD...
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