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Article

TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity

22 Dec 2014

Abstract excerpt

The p53-family member TAp73 is known to function as a tumor suppressor and regulates genomic integrity, cellular proliferation, and apoptosis; however, its role in tumor angiogenesis is poorly understood. Here we demonstrate that TAp73 regulates tumor angiogenesis through repression of proangiogenic and proinflammatory cytokines. Importantly, loss of TAp73 results in highly vascularized tumors, as well as an...

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PMID: 25535357
DOI: 10.1073/pnas.1421697112

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