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Article

CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer.

PLoS genetics - 1 May 2021

Malik Navdeep, Yan Hualong, Yang Howard H, Ayaz Gamze, DuBois Wendy, Tseng Yu-Chou, Kim Young-Im, Jiang Shunlin, Liu Chengyu, Lee Maxwell, Huang Jing

Abstract excerpt

The CBFB gene is frequently mutated in several types of solid tumors. Emerging evidence suggests that CBFB is a tumor suppressor in breast cancer. However, our understanding of the tumor suppressive function of CBFB remains incomplete. Here, we analyze genetic interactions between mutations of CBFB and other highly mutated genes in human breast cancer datasets and find that CBFB and TP53 mutations are mutually...

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Share to Cell Transformation, Neoplastic
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, Tumor Suppressor

Share to Receptor, Notch3

Share to Tumor Protein p73

Share to Tumor Suppressor Protein p53

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 33945523
DOI: 10.1371/journal.pgen.1009553
PMCID: PMC8121313

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