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Article

TAp73β and DNp73β activate the expression of the pro-survival caspase-2 S

8 Jul 2008

Abstract excerpt

p73, the p53 homologue, exists as a transactivation-domain-proficient TAp73 or deficient deltaN(DN)p73 form. Expectedly, the oncogenic DNp73 that is capable of inactivating both TAp73 and p53 function, is over-expressed in cancers. However, the role of TAp73, which exhibits tumour-suppressive properties in gain or loss of function models, in human cancers where it is hyper-expressed is unclear. We demonstrate...

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PMID: 18611950
DOI: 10.1093/nar/gkn414

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