Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ΔTAp73 Upregulation Correlates With Poor Prognosis in Human Tumors: Putative In Vivo Network Involving p73 Isoforms, p53, and E2F-1

28 Dec 2005

Abstract excerpt

PURPOSE: Although full-length TAp73 variants largely mimic p53 suppressor activities, the transactivation-deficient transcripts DeltaTAp73 exert an oncogenic effect by inactivating p53 and TAp73 suppressor properties. Additionally, DeltaTAp73 may cooperate with oncogenic RAS to induce cell transformation, confer drug resistance, and induce the phosphorylation of phosphorylated Rb. Here, we study the expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Breast Cancer Therapies
Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16380414
DOI: 10.1200/jco.2005.02.2350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ΔTAp73 Upregulation Correlates With Poor Prognosis in Human Tumors: Putative In Vivo Network Involving p73 Isoforms, p53, and E2F-1PMID 16380414Read ↗

Prognostic Impact of ΔTAp73 Isoform Levels and Their Target Genes in Colon Cancer PatientsSemantic proximity Read ↗

Transdominant ΔTAp73 Isoforms Are Frequently Up-regulated in Ovarian Cancer. Evidence for Their Role as Epigenetic p53 Inhibitors in VivoSemantic proximity Read ↗

Involvement of N-terminally truncated variants of p73, deltaTAp73, in head and neck squamous cell cancer: a comparison with p53 mutations.Semantic proximity Read ↗

DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors.Semantic proximity Read ↗

Clinical implications of the deregulated TP73 isoforms expression in cancerSemantic proximity Read ↗

In good times and bad: p73 in cancerSemantic proximity Read ↗

Isoform-specific Disruption of the <i>TP73</i> Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via LeptinSemantic proximity Read ↗

deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo.Semantic proximity Read ↗

Decreased expression of p73 in colorectal cancerSemantic proximity Read ↗

p63 and p73 in human cancer: defining the network.Semantic proximity Read ↗

Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes.Semantic proximity Read ↗

Mechanisms of Functional Pleiotropy of p73 in Cancer and BeyondSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.