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Article

Genotype-phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus.

Fungal genetics and biology : FG & B - 1 Sept 2015

Snelders Eveline, Camps Simone M T, Karawajczyk Anna, Rijs Antonius J M M, Zoll Jan, Verweij Paul E, Melchers Willem J G

Abstract excerpt

The Aspergillus fumigatus cyp51A gene TR46/Y121F/T289A mutation is a new emerging resistance mechanism with high-level voriconazole (VOR) resistance, and elevated MICs to all other medical azoles. This is highly worrisome as VOR is the primary drug for the treatment of many aspergillus diseases. The 46 base pair tandem repeat (TR46) is positioned at the same location of the cyp51A gene promoter region as has been...

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PMID: 26092193
DOI: 10.1016/j.fgb.2015.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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