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Article

cyp51A-based mechanism of azole resistance in Aspergillus fumigatus: Illustration by a new 3D Structural Model of Aspergillus fumigatus CYP51A protein.

Medical mycology - 1 May 2016

Liu Musang, Zheng Nan, Li Dongmei, Zheng Hailin, Zhang Lili, Ge Hu, Liu Weida

Abstract excerpt

Mutations of CYP51A protein (Cytochrome P450 14-α Sterol demethylase) play a central role in the azole resistance of Aspergillus fumigatus The available structural models of CYP51A protein ofA. fumigatus are built based on that of Homo sapiens and that of Mycobacterium tuberculosis, of which the amino acid homology is only 38% and 29% compared with CYP51A protein ofA. fumigatus, respectively. In the present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26768370
DOI: 10.1093/mmy/myv102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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