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Article

S292L mutation in Rv1258c efflux pump drives pyrazinamide efflux and a novel inhibitor designed for co-therapy to improve MDR-TB treatment outcomes.

World journal of microbiology & biotechnology - 7 Aug 2025

Singh Garima, Shreya Shriti, Yadav Saurabh, Akhter Yusuf

Abstract excerpt

Tuberculosis (TB) remains a major global health challenge, exacerbated by the rise of drug-resistant Mycobacterium tuberculosis (Mtb) strains that undermine first-line therapies. Resistance to pyrazinamide (PZA), an essential anti-TB drug, is often linked to mutations in the pncA gene and efflux pump genes such as Rv1258c. The Rv1258c efflux pump not only expels antibiotics, reducing intracellular drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40770126
DOI: 10.1007/s11274-025-04510-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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