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Article

Impact of chromosome alterations, genetic mutations and clonal hematopoiesis of indeterminate potential (CHIP) on the classification and risk stratification of MDS.

Blood cells, molecules & diseases - 1 Mar 2018

Ganguly Bani Bandana, Banerjee Debasis, Agarwal Mohan B

Abstract excerpt

The advent of technological development has undoubtedly advanced biological and molecular inputs for better understanding the heterogeneous hematopoietic pre-malignant disorder of the stem cells known as myelodysplastic syndromes (MDS). Chromosomal rearrangements, including del(3q/5q/7q/11q/12p/20q), loss of 5/7/Y, trisomy 8/19, i(17q), etc. frequently detected in MDS with variable frequencies and combinations,...

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Identifiers

PMID: 29079134
DOI: 10.1016/j.bcmd.2017.10.001

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