Article
IL1B rs1143627 and IL17A rs8193036 in the risk of Acute Graft Versus Host Disease in pediatric HSCT.
Leukemia research - 1 Apr 2026
Mootoosamy Covida, Ansari Marc, Gagné Vincent, Chatelain-Laflamme Antoine, Flament Charlenn, Zekraoui Othmane, Nyambi Maréva, Théorêt Yves, Nava Tiago, Mlakar Vid, Gloor Yvonne Sylvia, Villard Jean, Boelens Jaap-Jan, Bredius Robbert G M, Dalle Jean-Hugues, Lewis Victor, Kałwak Krzysztof, Sinnett Daniel, Bittencourt Henrique, Krajinovic Maja
Abstract excerpt
BACKGROUND: Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). While HLA compatibility is a key determinant, increasing evidence suggests that non-HLA immune gene polymorphisms, particularly those in cytokine genes, contribute to GVHD risk. OBJECTIVE: This study seeks to validate in a pediatric population, cytokine-related single nucleotide...
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