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Article

Donor Genetic Predisposition to High Interleukin-10 Production Appears Protective against Acute Graft-Versus-Host Disease.

International journal of molecular sciences - 14 Dec 2022

Tripathi Gaurav, Khanolkar Rutvij A, Faridi Rehan M, Kalra Amit, Dharmani-Khan Poonam, Shabani-Rad Meer-Taher, Berka Noureddine, Daly Andrew, Storek Jan, Khan Faisal M

Abstract excerpt

The persistence of graft-versus-host disease (GVHD) as the principal complication of allogeneic hematopoietic cell transplantation (HCT) demonstrates that HLA matching alone is insufficient to prevent alloreactivity. We performed molecular and functional characterization of 22 candidate cytokine genes for their potential to improve matching in 315 myeloablative, 10/10 HLA-matched donor−recipient pairs. Recipients...

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PMID: 36555525
DOI: 10.3390/ijms232415888
PMCID: PMC9779827

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