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Article

SAAMBE-SEQ: a sequence-based method for predicting mutation effect on protein-protein binding affinity.

Bioinformatics (Oxford, England) - 17 May 2021

Li Gen, Pahari Swagata, Murthy Adithya Krishna, Liang Siqi, Fragoza Robert, Yu Haiyuan, Alexov Emil

Abstract excerpt

MOTIVATION: Vast majority of human genetic disorders are associated with mutations that affect protein-protein interactions by altering wild-type binding affinity. Therefore, it is extremely important to assess the effect of mutations on protein-protein binding free energy to assist the development of therapeutic solutions. Currently, the most popular approaches use structural information to deliver the...

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PMID: 32866236
DOI: 10.1093/bioinformatics/btaa761
PMCID: PMC8128451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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