Article
Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis.
Annals of clinical and translational neurology - 1 Jun 2024
Kowalec Kaarina, Harder Arvid, Dolovich Casandra, Fitzgerald Kathryn C, Salter Amber, Lu Yi, Bernstein Charles N, Bolton James M, Cutter Gary, Fisk John D, Gelernter Joel, Graff Lesley A, Hägg Sara, Hitchon Carol A, Levey Daniel F, Lublin Fred D, McKay Kyla A, Patten Scott, Patki Amit, Stein Murray B, Tiwari Hemant K, Wolinsky Jerry S, Marrie Ruth A
Abstract excerpt
OBJECTIVE: Comorbid anxiety occurs often in MS and is associated with disability progression. Polygenic scores offer a possible means of anxiety risk prediction but often have not been validated outside the original discovery population. We aimed to investigate the association between the Generalized Anxiety Disorder 2-item scale polygenic score with anxiety in MS. METHODS: Using a case-control design,...
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