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Article

Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.

Nature genetics - 1 Oct 2024

Friligkou Eleni, Løkhammer Solveig, Cabrera-Mendoza Brenda, Shen Jie, He Jun, Deiana Giovanni, Zanoaga Mihaela Diana, Asgel Zeynep, Pilcher Abigail, Di Lascio Luciana, Makharashvili Ana, Koller Dora, Tylee Daniel S, Pathak Gita A, Polimanti Renato

Abstract excerpt

We leveraged information from more than 1.2 million participants, including 97,383 cases, to investigate the genetics of anxiety disorders across five continental groups. Through ancestry-specific and cross-ancestry genome-wide association studies, we identified 51 anxiety-associated loci, 39 of which were novel. In addition, polygenic risk scores derived from individuals of European descent were associated with...

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PMID: 39294497
DOI: 10.1038/s41588-024-01908-2

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