Article
Dietary n-3 alpha-linolenic and n-6 linoleic acids modestly lower serum lipoprotein(a) concentration but differentially influence other atherogenic lipoprotein traits: A randomized trial.
Atherosclerosis - 1 Aug 2024
Nuotio Petrus, Lankinen Maria A, Meuronen Topi, de Mello Vanessa D, Sallinen Taisa, Virtanen Kirsi A, Pihlajamäki Jussi, Laakso Markku, Schwab Ursula
Abstract excerpt
BACKGROUND AND AIMS: Lipoprotein(a) [Lp(a)] is a causal, genetically determined cardiovascular risk factor. Limited evidence suggests that dietary unsaturated fat may increase serum Lp(a) concentration by 10-15 %. Linoleic acid may increase Lp(a) concentration through its endogenous conversion to arachidonic acid, a process regulated by the fatty acid desaturase (FADS) gene cluster. We aimed to compare the Lp(a)...
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