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Article

Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils.

The American journal of clinical nutrition - 1 May 2020

Sergeant Susan, Hallmark Brian, Mathias Rasika A, Mustin Tammy L, Ivester Priscilla, Bohannon Maggie L, Ruczinski Ingo, Johnstone Laurel, Seeds Michael C, Chilton Floyd H

Abstract excerpt

BACKGROUND: Unexplained heterogeneity in clinical trials has resulted in questions regarding the effectiveness of ɣ-linolenic acid (GLA)-containing botanical oil supplements. This heterogeneity may be explained by genetic variation within the fatty acid desaturase (FADS) gene cluster that is associated with circulating and tissue concentrations of arachidonic acid (ARA) and dihomo-ɣ-linolenic acid (DGLA), both of...

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PMID: 32167131
DOI: 10.1093/ajcn/nqaa023
PMCID: PMC7198310

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Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils.PMID 32167131Read ↗

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