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Article

FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.

The Journal of nutrition - 1 Jul 2011

Dumont Julie, Huybrechts Inge, Spinneker Andre, Gottrand Frédéric, Grammatikaki Evangelia, Bevilacqua Noemi, Vyncke Krishna, Widhalm Kurt, Kafatos Anthony, Molnar Denes, Labayen Idoia, Gonzalez-Gross Marcela, Amouyel Philippe, Moreno Luis A, Meirhaeghe Aline, Dallongeville Jean

Abstract excerpt

Two rate-limiting enzymes in PUFA biosynthesis, Δ5- and Δ6-desaturases, are encoded by the FADS1 and FADS2 genes, respectively. Genetic variants in the FADS1-FADS2 gene cluster are associated with changes in plasma concentrations of PUFA, HDL- and LDL-cholesterol, and TG. However, little is known about whether dietary PUFA intake modulates these associations, especially in adolescents. We assessed whether dietary...

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Source

Identifiers

PMID: 21593353
DOI: 10.3945/jn.111.140392

Genes

FADS1
FADS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.PMID 21593353Read ↗

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FADS2 Variants are Associated with Omega-6 Metabolic Conversion in Serbian Adults in a cross-sectional study – Implications for Precision Nutrition PracticeSemantic proximity Read ↗

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