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Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits.

Clinical nutrition (Edinburgh, Scotland) - 1 Oct 2018

Dumont Julie, Goumidi Louisa, Grenier-Boley Benjamin, Cottel Dominique, Marécaux Nadine, Montaye Michèle, Wagner Aline, Arveiler Dominique, Simon Chantal, Ferrières Jean, Ruidavets Jean-Bernard, Amouyel Philippe, Dallongeville Jean, Meirhaeghe Aline

Abstract excerpt

BACKGROUND & AIMS: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Δ5- and Δ6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet. Genome-wide associations studies (GWAS) reported associations between polymorphisms in FADS1-FADS2 and variations in plasma concentrations of PUFAs, HDL- and LDL-cholesterol and triglycerides. However, it is not...

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Source

Identifiers

PMID: 28774683
DOI: 10.1016/j.clnu.2017.07.012

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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