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Article

Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease.

American journal of epidemiology - 15 Oct 2008

Kavvoura Fotini K, McQueen Matthew B, Khoury Muin J, Tanzi Rudolph E, Bertram Lars, Ioannidis John P A

Abstract excerpt

The authors evaluated whether there is an excess of statistically significant results in studies of genetic associations with Alzheimer's disease reflecting either between-study heterogeneity or bias. Among published articles on genetic associations entered into the comprehensive AlzGene database (www.alzgene.org) through January 31, 2007, 1,348 studies included in 175 meta-analyses with 3 or more studies each...

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Identifiers

PMID: 18779388
DOI: 10.1093/aje/kwn206
PMCID: PMC3695656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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