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Hepatitis B virus particles in serum contain minus strand DNA and degraded pregenomic RNA of variable and inverse lengths.

Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2024

Ringlander Johan, Malmström Sebastian, Eilard Anders, Strömberg Lucia Gonzales, Stenbäck Joakim B, Andersson Maria E, Larsson Simon B, Kann Michael, Nilsson Staffan, Hellstrand Kristoffer, Rydell Gustaf E, Lindh Magnus

Abstract excerpt

This study utilized digital PCR to quantify HBV RNA and HBV DNA within three regions of the HBV genome. Analysis of 75 serum samples from patients with chronic infection showed that HBV RNA levels were higher in core than in S and X regions (median 7.20 vs. 6.80 and 6.58 log copies/mL; p < .0001), whereas HBV DNA levels showed an inverse gradient (7.71 vs. 7.73 and 7.77 log copies/mL, p < .001). On average 80% of...

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Share to DNA, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38709598
DOI: 10.1111/liv.15955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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