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Circulating HBV RNA: From biology to clinical applications

28 Mar 2022

Abstract excerpt

Chronic HBV infection can hardly be cured due to the persistence of an intrahepatic pool of viral covalently closed circular DNA (cccDNA) transcription template, which is refractory to current antivirals. The direct analyses of cccDNA quantity and transcriptional activity require an invasive biopsy. Recently, circulating HBV RNA has been identified as a promising noninvasive surrogate marker of cccDNA and can be...

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PMID: 35342969
DOI: 10.1002/hep.32479

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