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Article

A novel method to precisely quantify hepatitis B virus covalently closed circular (ccc)DNA formation and maintenance

26 Jul 2020

Abstract excerpt

Hepatitis B virus (HBV) is the major cause of virus-associated liver disease. Persistent HBV infection is maintained by its episomal genome (covalently closed circular DNA, cccDNA), which acts as a template for viral transcripts. The formation of cccDNA is poorly characterised due to limited ability to quantify it accurately in the presence of replicative intermediates. Here, we describe a novel cccDNA...

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PMID: 32726641
DOI: 10.1016/j.antiviral.2020.104865

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