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Article

The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy.

Epilepsy research - 1 Jun 2011

Gulcebi Medine Idrizoglu, Ozkaynakcı Aydan, Goren Mehmet Zafer, Aker Rezzan Gulhan, Ozkara Cigdem, Onat Filiz Yılmaz

Abstract excerpt

Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects. High performance liquid...

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Identifiers

PMID: 21601426
DOI: 10.1016/j.eplepsyres.2011.01.016

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