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Article

Polymorphisms of ABCG2, ABCB1 and HNF4α are associated with Lamotrigine trough concentrations in epilepsy patients.

Drug metabolism and pharmacokinetics - 1 Aug 2015

Zhou Yafang, Wang Xueding, Li Hongliang, Zhang Jie, Chen Ziyi, Xie Wen, Zhang Jinxin, Li Jiali, Zhou Liemin, Huang Min

Abstract excerpt

Lamotrigine (LTG) is commonly used to control seizure in epilepsy patients and with referenced therapeutic windows in clinical practice. This study is to identify and characterize the function of genetic variants that influence the trough concentrations of LTG in epilepsy patients following monotherapy regimen (37.5-250 mg/d). Twelve single nucleotide polymorphisms (SNPs) involved in LTG metabolism and transport...

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Source

Identifiers

PMID: 26213157
DOI: 10.1016/j.dmpk.2015.05.002

Genes

ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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