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Article

Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy.

European journal of clinical pharmacology - 1 May 2016

Inoue Kazuyuki, Yamamoto Yoshiaki, Suzuki Eri, Takahashi Toshiki, Umemura Akiko, Takahashi Yukitoshi, Imai Katsumi, Inoue Yushi, Hirai Keita, Tsuji Daiki, Itoh Kunihiko

Abstract excerpt

PURPOSE: Lamotrigine (LTG) is used to treat epilepsy. The variability of LTG pharmacokinetics among individuals may be attributed to polymorphisms in the genes of uridine diphosphate glucuronosyltransferases (UGTs) 1A4 and UGT2B7 and/or combination with other drugs. In this study, we evaluated the association between LTG concentrations and patient characteristics such as genetic polymorphisms and the...

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Identifiers

PMID: 26790665
DOI: 10.1007/s00228-016-2008-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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