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Article

PTPN23[Thr] variant reduces susceptibility and tumorigenesis in esophageal squamous cell carcinoma through dephosphorylation of EGFR.

Cancer letters - 28 Jun 2024

Niu Siyuan, Ma Jialing, Li Yueping, Yue Xinying, Shi Ke, Pan Miaoxin, Song Lina, Tan Yuqian, Gu Linglong, Liu Shasha, Chang Jiang

Abstract excerpt

Post-translational modifications (PTMs) have emerged as pivotal regulators of the development of cancers, including esophageal squamous cell carcinoma (ESCC). Here, we conducted a comprehensive analysis of PTM-related genetic variants associated with ESCC risk using large-scale genome-wide and exome-wide association datasets. We observed significant enrichment of PTM-related variants in the ESCC risk loci and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Esophageal Squamous Cell Carcinoma

Share to Mice, Inbred BALB C

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Share to Protein Processing, Post-Translational

Share to Protein Tyrosine Phosphatases, Non-Receptor

Source

Identifiers

PMID: 38704135
DOI: 10.1016/j.canlet.2024.216936

Genes

PTPN23
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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