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Article

FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement.

Science advances - 3 May 2024

Khandelwal Nitin, Kulkarni Ashwinikumar, Ahmed Newaz I, Harper Matthew, Konopka Genevieve, Gibson Jay R

Abstract excerpt

Long-range glutamatergic inputs originating from the cortex and thalamus are indispensable for striatal development, providing the foundation for motor and cognitive functions. Despite their significance, transcriptional regulation governing these inputs remains largely unknown. We investigated the role of a transcription factor encoded by a high-risk autism-associated gene, FOXP1, in sculpting glutamatergic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38701209
DOI: 10.1126/sciadv.adm7039
PMCID: PMC11068015

Genes

FOXP1

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