Article
Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.
PLoS genetics - 1 Jul 2011
Vernes Sonja C, Oliver Peter L, Spiteri Elizabeth, Lockstone Helen E, Puliyadi Rathi, Taylor Jennifer M, Ho Joses, Mombereau Cedric, Brewer Ariel, Lowy Ernesto, Nicod Jérôme, Groszer Matthias, Baban Dilair, Sahgal Natasha, Cazier Jean-Baptiste, Ragoussis Jiannis, Davies Kay E, Geschwind Daniel H, Fisher Simon E
Abstract excerpt
Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2 gene cause a monogenic speech and language disorder. Reduced functional dosage of the mouse version (Foxp2) causes deficient cortico-striatal synaptic plasticity and impairs motor-skill learning....
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