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Article

High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL-17 against M. tuberculosis antigen.

Frontiers in immunology - 1 Jan 2024

Ogongo Paul, Tran Anthony, Marzan Florence, Gingrich David, Krone Melissa, Aweeka Francesca, Lindestam Arlehamn Cecilia S, Martin Jeffrey N, Deeks Steven G, Hunt Peter W, Ernst Joel D

Abstract excerpt

Background: Interleukin-17-producing CD4 T cells contribute to the control of Mycobacterium tuberculosis (Mtb) infection in humans; whether infection with human immunodeficiency virus (HIV) disproportionately affects distinct Th17-cell subsets that respond to Mtb is incompletely defined. Methods: We performed high-definition characterization of circulating Mtb-specific Th17 cells by spectral flow cytometry in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38698866
DOI: 10.3389/fimmu.2024.1378040
PMCID: PMC11064812

Genes

CD4
CCR6
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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