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Article

Pediatric Chordoma: A Tale of Two Genomes.

Molecular cancer research : MCR - 2 Aug 2024

O'Halloran Katrina, Hakimjavadi Hesamedin, Bootwalla Moiz, Ostrow Dejerianne, Kerawala Rhea, Cotter Jennifer A, Yellapantula Venkata, Kaneva Kristiyana, Wadhwani Nitin R, Treece Amy, Foreman Nicholas K, Alexandrescu Sanda, Velazquez Vega Jose, Biegel Jaclyn A, Gai Xiaowu

Abstract excerpt

Little is known about the genomic alterations in chordoma, with the exception of loss of SMARCB1, a core member of the SWI/SNF complex, in poorly differentiated chordomas. A TBXT duplication and rs2305089 polymorphism, located at 6q27, are known genetic susceptibility loci. A comprehensive genomic analysis of the nuclear and mitochondrial genomes in pediatric chordoma has not yet been reported. In this study, we...

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Identifiers

PMID: 38691518
DOI: 10.1158/1541-7786.MCR-23-0741
PMCID: PMC11296893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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