Article
Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.
PloS one - 1 Jan 2014
Choy Edwin, MacConaill Laura E, Cote Gregory M, Le Long P, Shen Jacson K, Nielsen Gunnlaugur P, Iafrate Anthony J, Garraway Levi A, Hornicek Francis J, Duan Zhenfeng
Abstract excerpt
The molecular mechanisms underlying chordoma pathogenesis are unknown. We therefore sought to identify novel mutations to better understand chordoma biology and to potentially identify therapeutic targets. Given the relatively high costs of whole genome sequencing, we performed a focused genetic analysis using matrix-assisted laser desorption/ionization-time of flight mass spectrometer (Sequenom iPLEX...
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