Article
Correction of aberrant growth preserves tissue homeostasis.
Nature - 17 Aug 2017
Brown Samara, Pineda Cristiana M, Xin Tianchi, Boucher Jonathan, Suozzi Kathleen C, Park Sangbum, Matte-Martone Catherine, Gonzalez David G, Rytlewski Julie, Beronja Slobodan, Greco Valentina
Abstract excerpt
Cells in healthy tissues acquire mutations with surprising frequency. Many of these mutations are associated with abnormal cellular behaviours such as differentiation defects and hyperproliferation, yet fail to produce macroscopically detectable phenotypes. It is currently unclear how the tissue remains phenotypically normal, despite the presence of these mutant cells. Here we use intravital imaging to track the...
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