Article

Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases

2016-06-13

Abstract excerpt

Genome wide association studies have identified numerous regions in the genome associated with hundreds of human diseases. Building accurate genetic risk prediction models from these data will have great impacts on disease prevention and treatment strategies. However, prediction accuracy remains moderate for most diseases, which is largely due to the challenges in identifying all the disease-associated variants an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 96f357a4-cf23-5bbf-9933-23660c8416a2
DOI: 10.1101/058768

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex DiseasesDOI 10.1101/058768Read

Leveraging functional annotations in genetic risk prediction for human complex diseases.Semantic proximity Read

Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries.Semantic proximity Read

A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants.Semantic proximity Read

Using Full Genomic Information to Predict Disease: Breaking Down the Barriers Between Complex and Mendelian Diseases.Semantic proximity Read

Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction.Semantic proximity Read

DIVAN: accurate identification of non-coding disease-specific risk variants using multi-omics profiles.Semantic proximity Read

Practical issues in building risk-predicting models for complex diseases.Semantic proximity Read

Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets.Semantic proximity Read

Whole genome base-wise aggregation and functional prediction for human non-coding regulatory variantsSemantic proximity Read

GenRisk: a tool for comprehensive genetic risk modeling.Semantic proximity Read

Prioritization and functional assessment of noncoding variants associated with complex diseases.Semantic proximity Read

A machine-learning framework to characterize functional disease architectures and prioritize disease variantsSemantic proximity Read