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BRAFV600E promotes anchorage-independent growth but inhibits anchorage-dependent growth in hTERT/Cdk4-Immortalized normal human bronchial epithelial cells.

Experimental cell research - 1 Jun 2024

Muraki Nao, Kawabe Nozomi, Ohashi Ayano, Umeda Kanna, Katsuda Masahito, Tomatsu Aya, Yoshida Mikina, Komeda Kazuki, Minna John D, Tanaka Ichidai, Morise Masahiro, Matsushima Miyoko, Matsui Yusuke, Kawabe Tsutomu, Sato Mitsuo

Abstract excerpt

Certain oncogenes, including mutant RAS and BRAF, induce a type of senescence known as oncogene-induced senescence (OIS) in normal cells in a cell-type-specific manner. OIS serves as a barrier to transformation by activated oncogenes. Our previous studies showed that mutant KRASV12 did not efficiently induce OIS in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line (HBEC3), but it did enhance...

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PMID: 38679315
DOI: 10.1016/j.yexcr.2024.114057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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